Table 3. Pre-diagnostic wine consumption and overall survival after colorectal cancer diagnosis by patient and tumor attributes.
| No wine (<1 serving/week)† |
≤1 serving/day of wine (≥1 serving/week)† |
>1 servings/day of wine† | ||||||
|---|---|---|---|---|---|---|---|---|
|
|
||||||||
| N (deaths) | HR (95% CI)* | N (deaths) | HR (95% CI)* | P | N (deaths) | HR (95% CI)* | P | |
| Sex | ||||||||
| Male | 1674 (725) | 1.0 (ref) | 554 (196) | 0.87 (0.71-1.05) | 0.15 | 138 (46) | 0.61 (0.42-0.90) | 0.01 |
| Female | 1598 (573) | 1.0 (ref) | 484 (152) | 1.07 (0.85-1.33) | 0.57 | 91 (24) | 0.81 (0.52-1.24) | 0.32 |
| Age at diagnosis | ||||||||
| ≤50 | 1562 (506) | 1.0 (ref) | 509 (149) | 0.95 (0.77-1.18) | 0.66 | 89 (20) | 0.63 (0.38-1.03) | 0.07 |
| >50 | 1710 (792) | 1.0 (ref) | 529 (199) | 0.97 (0.80-1.18) | 0.77 | 140 (50) | 0.73 (0.51-1.03) | 0.07 |
| Smoking history | ||||||||
| Never smoker | 1449 (472) | 1.0 (ref) | 453 (139) | 1.03 (0.82-1.29) | 0.73 | 65 (14) | 0.73 (0.39-1.37) | 0.27 |
| Former smoker | 1.0 (ref) | 459 (151) | 0.77 (0.62-0.97) | 114 (38) | 0.62 (0.42-0.91) | 0.02 | ||
| Current smoker | 1185 (527) 638 (299) | 1.0 (ref) | 126 (58) | 1.41 (1.00-1.98) | 0.02 0.05 | 50 (18) | 0.77 (0.44-1.37) | 0.42 |
| Tumor site | ||||||||
| Right-sided | 1133 (485) | 1.0 (ref) | 342 (122) | 1.01 (0.79-1.28) | 0.96 | 65 (19) | 0.66 (0.39-1.13) | 0.13 |
| Left-sided | 970 (350) | 1.0 (ref) | 272 (83) | 1.14 (0.85-1.52) | 0.39 | 67 (18) | 0.59 (0.33-1.02) | 0.06 |
| Rectal | 1139 (447) | 1.0 (ref) | 410 (137) | 0.91 (0.72-1.17) | 0.47 | 97 (33) | 0.81 (0.54-1.21) | 0.30 |
| MMR status | 2210 | 1.0 (ref) | ||||||
| Proficient | (889) 377 | 775 (269) | 0.97 (0.82-1.14) | 0.69 | 172 (58) | 0.76 (0.55-1.05) | 0.10 | |
| Deficient | (113) | 1.0 (ref) | 96 (15) | 0.54 (0.29-1.02) | 0.06 | 22 (4) | -- | |
| BRAF-mutation status | ||||||||
| Wildtype | 1852 | 1.0 (ref) | 696 (226) | 1.03 (0.85-1.23) | 0.78 | 162 (56) | 0.82 (0.59-1.14) | 0.25 |
| Mutated | (716)251 (107) | 1.0 (ref) | 73 (24) | 1.24 (0.70-2.20) | 0.47 | 19 (3) | -- | |
| CIMP status | ||||||||
| Non-CIMP | 1371 | 1.0 (ref) | 484 (172) | 0.91 (0.73-1.13) | 0.39 | 116 (39) | 0.70 (0.47-1.02) | 0.07 |
| CIMP-high | (581)246 (114) | 1.0 (ref) | 54 (19) | 1.05 (0.58-1.90) | 0.52 | 11 (3) | -- | |
†
Unadjusted 5-year survival %: <1 serving/week (74.6%), ≤1 serving/day (≥1 serving/week) (77.7%), >1 serving/day (82.1%)
*
Adjusted for age at diagnosis, year of diagnosis, sex, smoking history, body mass index, education, study site
-- Result based on <5 deaths in one comparison group