Table 4. Pre-diagnostic wine consumption and disease-specific survival after colorectal cancer diagnosis by patient and tumor attributes.
| No wine (<1 serving/week)† |
≤1 serving/day of wine (≥1 serving/week)† |
>1 servings/day of wine† | ||||||
|---|---|---|---|---|---|---|---|---|
|
|
||||||||
| N (deaths) | HR (95% CI)* | N (deaths) | HR (95% CI)* | P | N (deaths) | HR (95% CI)* | P | |
| Sex | ||||||||
| Male | 1622 (423) | 1.0 (ref) | 527 (121) | 0.85 (0.66-1.10) | 0.22 | 131 (24) | 0.57 (0.34-0.97) | 0.04 |
| Female | 1552 (349) | 1.0 (ref) | 468 (101) | 1.10 (0.83-1.46) | 0.50 | 88 (18) | 0.92 (0.56-1.52) | 0.76 |
| Age at diagnosis | ||||||||
| ≤50 | 1499 (363) | 1.0 (ref) | 485 (109) | 1.01 (0.78-1.30) | 0.94 | 82 (13) | 0.63 (0.34-1.18) | 0.15 |
| >50 | 1675 (409) | 1.0 (ref) | 510 (113) | 0.93 (0.71-1.22) | 0.59 | 137 (29) | 0.74 (0.46-1.18) | 0.20 |
| Smoking history | ||||||||
| Never smoker | 1408 (302) | 1.0 (ref) | 432 (92) | 1.01 (0.76-1.34) | 0.88 | 64 (9) | 0.82 (0.39-1.73) | 0.59 |
| Former smoker | 1159 (300) | 1.0 (ref) | 441 (86) | 0.70 (0.51-0.96) | 0.01 | 108 (21) | 0.59 (0.36-0.98) | 0.04 |
| Current smoker | 607 (170) | 1.0 (ref) | 122 (44) | 1.80 (1.21-2.67) | 0.004 | 47 (12) | 0.82 (0.40-1.68) | 0.64 |
| Tumor site | ||||||||
| Right-sided | 1100 (260) | 1.0 (ref) | 330 (86) | 1.31 (0.98-1.76) | 0.07 | 63 (14) | 0.92 (0.48-1.75) | 0.79 |
| Left-sided | 943 (201) | 1.0 (ref) | 256 (42) | 0.76 (0.49-1.20) | 0.24 | 62 (9) | 0.44 (0.20-0.96) | 0.04 |
| Rectal | 1103 (302) | 1.0 (ref) | 397 (91) | 0.89 (0.66-1.20) | 0.45 | 94(19) | 0.72 (0.42-1.22) | 0.22 |
| MMR status | ||||||||
| Proficient | 2154 (558) | 1.0 (ref) | 740 (172) | 0.91 (0.73-1.13) | 0.39 | 164 (35) | 0.76 (0.51-1.15) | 0.19 |
| Deficient | 374 (44) | 1.0 (ref) | 96 (7) | 0.56 (0.24-1.33) | 0.19 | 21 (2) | -- | |
| BRAF-mutation status | ||||||||
| Wildtype | 1816 (435) | 1.0 (ref) | 666 (138) | 0.90 (0.71-1.14) | 0.39 | 156 (35) | 0.80 (0.53-1.23) | 0.32 |
| Mutated | 243 (44) | 1.0 (ref) | 72 (20) | 1.76 (0.93-3.33) | 0.08 | 19 (3) | -- | |
| CIMP status | 1.0 (ref) | 464 (106) | 0.82 (0.62-1.09) | 0.18 | 115 (25) | 0.71 (0.44-1.16) | 0.18 | |
| Non-CIMP | 1346 (356) | |||||||
| CIMP-high | 242 (51) | 1.0 (ref) | 54 (13) | 0.96 (0.46-1.99) | 0.91 | 11 (3) | -- | |
†
Unadjusted 5-year survival %: <1 serving/week (80.2%), ≤1 serving/day (≥1 serving/week) (81.4%), >1 serving/day (84.7%)
*
Adjusted for age at diagnosis, year of diagnosis, sex, smoking history, body mass index, education, study site
-- Result based on <5 deaths in one comparison group