TABLE 2.
Outcome of SHIVmn229 viral challenge
| Group | SHIVmn229 viral load
|
% CD4+ CD3+ T cells at set point
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Peak viral load (log10 copies/ml)
|
Set pointa viral load (log10 copies/ml)
|
||||||||||||
| Mean | Range | Pb vs. controls | Mean | Range |
P
|
Mean | Range |
P
|
|||||
| Vs. controls | Vs. 2DNA/FPV | Vs. 3DNA | Vs. controls | Vs. 2DNA/FPV | Vs. 3DNA | ||||||||
| Control | 8.2 | 7.8-8.6 | 6.2 | 5.4-6.7 | 0.5 | 0.05-2.0 | |||||||
| 2DNA/FPV | 6.7 | 5.1-7.9 | 0.004 | 4.9 | 4.4-5.4 | 0.002 | 12.3 | 0.7-21.5 | 0.006 | ||||
| 3DNA | 6.7 | 4.7-8.2 | 0.016 | 4.8 | 3.8-6.0 | 0.011 | 0.785 | 11.4 | 0.6-22.6 | 0.033 | 0.92 | ||
| 1DNA/FPV | 7.4 | 5.9-8.6 | 0.09 | 5.95 | 5.3-6.6 | 0.565 | 0.006 | 0.031 | 1.8 | 0.1-4.2 | 0.154 | 0.023 | 0.082 |
| 2DNA/FPV-IFN-γ | 7.4 | 6.6-8.2 | 0.02 | 5.6 | 4.0-6.5 | 0.224 | 0.107 | 0.139 | 2.3 | 0.1-8.7 | 0.216 | 0.021 | 0.073 |
Set point values taken from weeks 5, 8, and 11 postchallenge.
P represents the P value for pairwise comparisons between the group noted and the other vaccine groups.