Table 4. Mixed patterns assigned by manual IIF method and EUROPattern Suite (N=21).
| Patients | Diagnosis | Method | ||
|---|---|---|---|---|
| IIF Method | EUROPattern | |||
| Matched (7) | 1 | Systemic lupus erythematosus | Homogenous/Nucleolar (1:640 / 1:320) | |
| 2 | Neuromyelitis optica, Sjogren's syndrome | Homogenous/Nucleolar (1:320 / 1:640) | ||
| 3 | Primary biliary cirrhosis | Homogenous/Nucleolar (1:640 / 1:640) | ||
| 4 | Seropositive RA | Homogenous/Speckled (1:640 / 1:320) | ||
| 5 | Systemic lupus erythematosus | Homogenous/Speckled (1:160 / 1:640) | ||
| 6 | Traumatic arthritis | Homogenous/Nuclear dot (1:160 / 1:320) | ||
| 7 | Autoimmune hepatitis | Homogenous/Centromere/Nucleolar (1:640 / 1:640 / 1:640) | ||
| Mismatched (14) | 8 | SLE with Sjogren's syndrome | Homogenous/Centromere (1:80 / 1:640) | Homogenous/Centromere/Nucleolar |
| 9 | Autoimmune hepatitis | Homogenous/Centromere (1:320 / 1:640) | Homogenous/Centromere/Speckled | |
| 10 | IPF | Homogenous/Centromere (1:640 / 1:640) | Homogenous/Nucleolar/Speckled | |
| 11 | Seasonal allergy | Homogenous/Nuclear dot (1:320 / 1:640) | Homogenous/Nuclear dot/Nucleolar | |
| 12 | Morphea | Homogenous/Nuclear dot (1:320 / 1:640) | Homogenous/Nuclear dot/Nucleolar | |
| 13 | Autoimmune hepatitis | Homogenous/Nuclear membrane (1:320 / 1:160) | Homogenous/Nuclear membrane/Speckled | |
| 14 | Sjogren's syndrome | Speckled/Nucleolar (1:640 / 1:640) | Speckled/Nucleolar/Homogenous | |
| 15 | Primary biliary cirrhosis | Speckled/Centromere (1:160 / 1:640) | Speckled/Centromere/Nuclear dot/Homogenous | |
| 16 | Nonalcoholic fatty liver disease | Nucleolar/Speckled (1:640 / 1:640) | Nucleolar/Homogenous | |
| 17 | Acute interstitial nephritis | Centromere/Nuclear membrane (1:640 / 1:640) | Centromere/Nuclear membrane/Speckled | |
| 18 | Autoimmune hepatitis | Homogenous/Centromere/Nuclear membrane (1:320 / 1:640 / 1:160) | Homogenous/Centromere | |
| 19 | Primary biliary cirrhosis | Nucleolar/Nuclear dot* (1:160 / 1:160) | Nucleolar | |
| 20 | Proteinuria | Nuclear dot/Homogenous† (1:320 / 1:80) | Nuclear dot | |
| 21 | Interstitial lung disease | Speckled/Nucleolar‡ (1:640 / 1:640) | Speckled | |
The numbers in parenthesis indicate the number of samples.
*The titer of the missing pattern was 1:160; †The titer of the missing pattern was 1:80; ‡The titer of the missing pattern was 1:640.
Abbreviations: IIF, indirect immunofluorescence; IPF, idiopathic pulmonary fibrosis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus.