Fig. 1. The longitudinal patterns of CMV pp65 antigenemia and CMV-specific T-cell response measured by using the QuantiFERON-CMV assay in three allogeneic HSCT recipients. (A) Nine-year-old female patient with aplastic anemia with repeated positive QuantiFERON-CMV assay results during the early phase of CMV infection. (B) Eleven-month-old male patient with juvenile myelomonocytic leukemia who converted from indeterminate and negative to positive QuantiFERON-CMV results during the course of infection. (C) Twenty-eight-month-old female patient with neuroblastoma with persistent negative results, except for a single positive result during the early transplant phase; the patient died because of tumor progression at 140 days post HSCT. ‘+’ indicates a positive QF-CMV result, ‘-’ indicates a negative result, and ‘♦’ indicates an indeterminate result.

Abbreviations: CMV, cytomegalovirus; HSCT, hematopoietic stem cell transplantation; WBCs, white blood cells.