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. 2017 Mar 7;8:103. doi: 10.3389/fphar.2017.00103

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Copyright © 2017 Gilligan, Gondal, Tang, Hussain, Arvaniti, Hewitt and Foster.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Steroid sulfatase activity (E₁S conversion in pmol/mg/h) and inhibition by STX64 (1 μM) in intact CRC cell lines. (B) STS activity and inhibition by STX64 (1 μM) in CRC cell lysate. JEG3 cells were used as a positive control in all experiments. Data represents mean ± SD. n = 3 independent experiments.