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. 2017 Mar 7;8:103. doi: 10.3389/fphar.2017.00103

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Copyright © 2017 Gilligan, Gondal, Tang, Hussain, Arvaniti, Hewitt and Foster.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OATP4A1 knockdown in HCT116 cells blocks E₁S transport. (A) siRNA knockdown of OATP2B1 and OATP4A1 reduced transporter expression by over 95%. (B) In HCT116 cells OATP2B1 knockdown has no effect on E₁S transport, however OATP4A1 knockdown inhibited E₁S transport by 52.4%. Data represents mean ± SD. n = 3 independent experiments. ^∗∗p < 0.01 compared to control.