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. 2017 Mar 7;8:103. doi: 10.3389/fphar.2017.00103

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Copyright © 2017 Gilligan, Gondal, Tang, Hussain, Arvaniti, Hewitt and Foster.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Steroid sulfatase activity is regulated by estrogen availability in CRC cell lines. (A) E₂ (100 nM) does not increase STS activity in HT29. (B) E₂ (100 nM) significantly increase STS activity in HCT116 cells. (C) 24 h treatment of Tamoxifen (10 nM) and fulvestrant (1 mM) increases STS activity in HCT116 cells. (D) Colo205 and Caco2 cells express ERα, but not ERβ. HCT116 and HT29 cells do not express ERα or ERβ. The +ive control is MCF-7 protein. (E) GPER is expressed in HCT116 and HT29 cells. Data represents mean ± SD. n = 3 independent experiments. ^∗p < 0.05, ^∗∗p < 0.01 compared to sFBS control.