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. 2017 Mar 7;11:67. doi: 10.3389/fncel.2017.00067

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Copyright © 2017 Yu, Wang, Zhao, Zhang, Tao, Shi, Sun and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sodium hydrosulfide (NaHS) protects oxygen-glucose deprivation (OGD)-induced impairments in young and aged primary cultures of hippocampal neurons dose-dependently. (A) Representative images of the young and aged cultures under 2 h OGD treatment in the presence of different concentrations of NaHS (0, 10, 50, 250, and 1,000 μM) for 7 days. Scale bar = 30 μm. (B) Relative cell viability of the cultures to control (no OGD and NaHS treatment) under OGD treatment following different NaHS treatment, measured by MTT assay. (C) Relative lactate Dehydrogenase (LDH) release to control in the experimental groups. Data were presented by the mean ± SD. ^∗p < 0.05 and ^∗∗p < 0.01 versus control, ^#p < 0.05 and ^##p < 0.01 versus OGD group.