Table 4.

Intervention related changes in gray matter volume, and volume and microstructure of the hippocampus of MCI patients dependent on group and time.

	Resveratrol (n = 14)			Placebo (n = 16)
	BL	FU	p-valuea	BL	FU	p-valuea	Unadjusted p-value (group × time)b	Adjusted p-value (group × time)c
Total GM volume [cm3]	542.8±68.6	540.6±65.1	0.454	552.1±50.5	547.0±55.6	0.301	0.606	0.744
HC, LEFT
Volume [cm3]	3.52±0.6	3.53±0.6	0.774	3.78±0.6	3.62±0.5	0.073	0.084	0.113
MD [m2/s]	1.10±0.19	1.12±0.14	0.629	1.14±0.09	1.14±0.11	0.736	0.544	0.131
HC, LEFT ANT
Volume [cm3]	2.04±0.4	2.06±0.3	0.583	2.24±0.3	2.14±0.3	0.063	0.061	0.061
MD [m2/s]	1.16±0.16	1.15±0.17	0.850	1.17±0.10	1.17±0.13	0.686	0.899	0.380
HC, LEFT POST
Volume [cm3]	1.47±0.2	1.47±0.3	0.863	1.55±0.2	1.48±0.2	0.133	0.222	0.340
MD [m2/s]	1.09±0.20	1.07±0.10	0.503	1.09±0.08	1.09±0.1	0.803	0.620	0.468
HC, RIGHT
Volume [cm3]	3.71±0.5	3.75±0.5	0.463	3.82±0.6	3.72±0.6	0.257	0.183	0.107
MD [m2/s]	1.09±0.12	1.15±0.09	0.029	1.16±0.09	1.18±0.11	0.171	0.275	0.063
HC, RIGHT ANT
Volume [cm3]	2.17±0.3	2.18±0.3	0.848	2.26±0.4	2.20±0.3	0.253	0.316	0.168
MD [m2/s]	1.16±0.10	1.20±0.11	0.007	1.21±0.12	1.23±12.8	0.266	0.374	0.429
HC, RIGHT POST
Volume [cm3]	1.53±0.2	1.57±0.2	0.218	1.56±0.3	1.52±0.2	0.231	0.093	0.071
MD [m2/s]	1.04±0.08	1.06±0.09	0.073	1.09±0.07	1.12±0.1	0.252	1.000	0.453

Number of words in different subtests of the auditory verbal learning test expressed as mean ± SD (raw data). Ant, anterior; BL, baseline; FU, follow-up; HC, hippocampus; MD, mean diffusivity; post, posterior.

^aPaired t-test.

^bANOVA_RM, unadjusted.

^cANCOVA_RM, adjusted for age, sex, and APOE e4 status.

Significant results are highlighted in bold (p < 0.05).