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. 2017 Mar 7;8:240. doi: 10.3389/fimmu.2017.00240

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Copyright © 2017 Hachmo, Kalechman, Skornick, Gafter, Caspi and Sredni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment with AS101 decreases glomerular macrophage accumulation in crescentic glomerulonephritis. Treatment protocol was as described in Figure 2. Immunohistochemistry was performed on kidney sections for detection of glomerular ED-1 positive accumulation on week 2 (A). Glomerular macrophages were counted under light microscope. One hundred glomeruli were counted/sample. Treatment starting at day 3 was examined only at week 4 (B). Data are presented as mean ± SE of five rats/group for each time point. ^#p < 0.01 increase vs. control; **p < 0.01 decrease vs. αGBM. The two-way ANOVA was used.