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Antiviral efficacy of HIV-1-specific siRNAs for HIV-1 NL4-3 infection in HeLaCD4 cells. HeLaCD4 cells were transfected with siRNAs and then infected with HIV-1 NL4-3 (MOI, 0.1 pg of p24/cell). HIV-1 p24 antigen levels in culture supernatants were measured at 1 and 2 dpi. The means of three experiments and the standard deviations are indicated. siRNAs 5, 6, and 8 exerted the most potent inhibition of NL4-3 infection.
