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. 2016 Dec 13;31(3):731–734. doi: 10.1038/leu.2016.315

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Copyright © 2017 The Author(s)

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PDLTC-PH contains cells with leukemia-initiating potential in vivo. (a) Xenograft transplantation of PDLTC-PH cells. Survival and leukemic peripheral blood engraftment of NSG mice (n=7) receiving bulk PDLTC-PH cells. (b) Surface CD34 and CD38 expression of PDLTC-PH cells via FACS. (c) Xenograft transplantation of prospectively FACS-enriched PDLTC-PH subpopulations. Survival of transplanted NSG mice (n=3 mice per subpopulation). No significant difference calculated by the log-rank test. The experiment was performed in a randomized and blinded way. One mouse of the CD34−CD38+ group died within the first week, caused by the transplantation procedure, and was excluded. The mean and s.d. are displayed.