Skip to main content
. 2017 Feb 13;40(2):123–132. doi: 10.14348/molcells.2017.2228

Fig. 5. MiR-33 and IRS-2 expression in the insulin target tissues of wild type (Irs-1+/+), heterozygous (Irs-1+/−), and homozygous (Irs-1−/−) mice.

Fig. 5

(A) MiR-33 expression in liver, skeletal muscle, and subcutaneous fat. MiR-33 expression was significantly reduced in all three tissues of homozygous and heterozygous mice compared with wild type mice. (B) Irs-2 expression in liver, skeletal muscle, and subcutaneous fat. Irs-2 expression was significantly increased in homozygous mice compared with wild type mice in liver and subcutaneous fat but not in skeletal muscle. On the other hand, Irs-2 expression was significantly increased in heterozygous mice compared with wild type mice in the skeletal muscle and subcutaneous fat but not in liver. *P < 0.05, **P < 0.01, ***P < 0.001.