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. 2017 Mar 6;149(3):301–322. doi: 10.1085/jgp.201611724

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© 2017 Chang et al.

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Figure 9. — Composite lipid–protein fusion pores. SNAREs are green; synaptophysin TMDs are pink. Models 1–3 illustrate continuity of the proximal monolayer of the vesicle and plasma membrane outside a proteinaceous fusion pore. These models have no contact between phospholipids and the aqueous pore lumen. Models 4–5 illustrate lipid headgroups of a bilayer that forms a pore in which lipid and protein alternate along the walls. Model 6 illustrates protein TMDs lodged among the headgroups of a lipidic fusion pore.