Table 4.

The relevant information about researches on CHB.

Reference	Methods	Sample	Main findings
[32]	UPLC-TripleTOF-MS/MS	Serum	Lysophosphatidylcholine, 3-oxodecanoic acid, and bile acids (TCA, GCA, and TCDCA) had high diagnostic value on immune clearance; oleamide amide was elevated in the three groups of CHB but was more notable in the inactive phase and had high diagnostic value on inactive phase.
[33]	UPLC-QTOF-MS	Urine	Biotin sulfone, 5-oxo-heneicosanoic acid, d-Glucosaminide, and 2-methylhippuric acid were the most significant differential metabolites for the classification of the HBV and the control.
[34]	GC-TOF-MS	Serum	Citric acid, aconitic acid, glutamine, N,N-dimethyl glycine, and malonic acid had good correlation with hepatitis B and had high sensitivity and specificity to differentiate CHB from control.
[35]	1H-NMR	Cell fluid	Uridine, inosine, guanosine, uracil, and xanthine were all significantly decreased.