TABLE 1.
Population mean parameter estimates for analyses 1 and 2 for macaques and humansa
| Parameter or statistic | Macaques |
Humans |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| All (analysis 1) |
Covariates (analysis 2) |
All (analysis 1) |
Covariates (analysis 2) |
|||||||
| Value | RSE (%) | Subpop. | Value | RSE (%) | Value | RSE (%) | Subpop. | Value | RSE (%) | |
| Parameter (unit) | ||||||||||
| Initial no. of TEM cells (TEM0) (cells) (E) | 20.7 | 29 | Chi | 0.29 | 39* | 59.9 | 17 | BCG: Y | 149 | 15 |
| Maur | 65.1 | 24 | ||||||||
| Indo | 23.2 | 41* | BCG: N | 30.6 | 14 | |||||
| R: Ind | 15.7 | 20 | ||||||||
| Gamma PDF curve multiplier (L) (scalar) (E) | 1,170 | 13 | Chi | 617 | 43* | 1,490 | 14 | BCG: Y | 3,240 | 14 |
| Maur | 1,460 | 28 | ||||||||
| Indo | 1,100 | 45* | BCG: N | 747 | 14 | |||||
| R: Ind | 1,250 | 14 | ||||||||
| Gamma PDF curve shape parameter (k) (scalar) (E) | 3.31 | 5 | Chi | 4.3 | 11 | 1.45 | 9 | 1.55 | 16 | |
| Maur | 3.15 | 10 | ||||||||
| Indo | 3 | 20 | ||||||||
| R: Ind | 3.53 | 6 | ||||||||
| Gamma PDF curve scale parameter (h) (scalar) (E) | 15 | 8 | 13.8 | 7 | 18.4 | 18 | BCG: Y | 21.7 | 24 | |
| BCG: N | 15.2 | 34* | ||||||||
| Initial no. of CM cells (CM0) (cells) (F) | 0 | 0 | 0 | 0 | ||||||
| TEM cell terminal mortality rate (μTEM) (/day) (F) | 0.1 | 0.1 | 0.083 | 0.083 | ||||||
| Proportion of TEM cells that die (p) (proportion) (F) | 0.925 | 0.925 | 0.925 | 0.925 | ||||||
| Within-population variation (WPV) (%) | ||||||||||
| Initial TEM cell population (TEM0) | 130 | 25 | 41 | 27 | 107 | 15 | 52 | 19 | ||
| Gamma PDF curve multiplier (L) | 96 | 13 | 90 | 13 | 95 | 10 | 61 | 12 | ||
| Gamma PDF curve shape parameter (k) | 24 | 24 | 23 | 24 | 25 | 28 | 32 | 33* | ||
| Gamma PDF curve scale parameter (h) | 19 | 21 | 21 | 20 | 58 | 25 | 43 | 37* | ||
| Goodness-of-fit statistics | ||||||||||
| −2LL | 7,209 | 7,183 | 2,738 | 2,653 | ||||||
| BIC | 7,253 | 7,251 | 2,779 | 2,706 | ||||||
a
For details on the parameter-covariate relationship, see the supplemental material. F, fixed; E, estimate; TEM, transitional effector memory; CM, central memory; PDF, probability density function; RSE, relative standard error; subpop., subpopulation; Chi, Chinese cynomolgus macaques; Maur, Mauritian cynomolgus macaques; Indo, Indonesian cynomolgus macaques; R: Ind, Indian rhesus macaques; BCG: Y, human participants who were BCG vaccinated at baseline; BCG: N, human participants who were BCG naive at baseline; −2LL, −2 log likelihood; BIC, Bayesian information criteria. RSEs of ≥30% are marked with asterisks.