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. 2017 Mar 7;11:62. doi: 10.3389/fncel.2017.00062

Figure 2.

Figure 2

Assembly of the imprinted Ube3a locus in the genomes of placental mammals. (A) A schematic representation of arrangements of Ube3a in vertebrate genomes. Genes are represented as boxes, and triangles indicate their transcriptional directions. The same colors indicate the same genes across species. The conserved arrangement of Ube3a and SNRPN upstream reading frame (SNURF)–small nuclear ribonucleoprotein-associated protein N (SNRPN) in placental mammals is enclosed by a red dashed box. The arrow indicates the chromosomal position of the Prader-Willi syndrome-Angelman syndrome imprinting center (PWS-AS IC) located upstream of the SNURF–SNRPN gene in placental mammals. Hsa, Homo sapiens; Ptr, Pan troglodytes; Mmu, Mus musculus; Cfa, Canis lupus familiaris; Mdo, Monodelphis domestica; Gga, Gallus gallus; Dre, Danio rerio; Chr, chromosomal location in each species; m, maternally expressed gene in humans; p, paternally expressed gene in humans. (B) A schematic representation of the arrangement of SNRPB in vertebrate genomes. The tandem duplication of SNRPN from SNRPB in the opossum genome is enclosed by a red dashed box. (C) Early origin and evolution of Ube3a in relation to the evolution of the nervous system. LECA, last eukaryotic common ancestor.