Table 1.

The LD50 values of saffron, safranal and crocin

Toxicity	Components	Animals	Route of administration	LD50	Ref
Acute	Saffron (aqueous extract)	BALB/c mice	Oral	4120±556 mg/kg	(18)
	Saffron (stigma extract)	mice	IP	1.6 g/kg	(18)
	Saffron (petal extract)	mice	IP	6 g/kg	(18)
	Safranal	Male BALB/c mice Female BALB/c mice Male Wistar rats	IP	1.48 ml/kg 1.88 ml/kg 1.50 ml/kg	(18)
		Male BALB/c mice Female BALB/c mice Male Wistar rats	Oral	21.42 ml/kg 11.42 ml/kg 5.53 ml/kg	(18)
	Crocin	Male Razi mice Wistar rats (150-210 g)	IP	1–5 g/kg	(21)