Table 3.

The effect of saffron and crocin on biochemical parameters in volunteers

Duration of exposure	Dose		Significant side effect	N	Ref.
	1 week Treatment, At 1 month monitoring	Saffron				Crocin		60	(15)
Tablet/ 200 mg/day, 400 mg/day		-	None
12 weeks	Capsule/ 30 mg/day	Capsule/ 30 mg/day	Crocin significantly Decreased the FBS Level	66	(50)
12 weeks	Capsule/ 15 mg twice daily	Capsule/ 15 mg twice time a day	WBC count increased significantly in patients receiving saffron, but it was within the normal range	66	(51)
One month	-	Tablet/ 20 mg	Significant decreased in amylase, mixed white blood cells and PTT	42	(37)
1 week	Tablet/ 200 mg/day, 400 mg/day	-	At dose of 400 mg: significant decrease in standing systolic blood pressure, mean arterial pressures, RBC and increase in Na+, BUN and creatinine	30	(36)
			At dose of 200 mg: Decrease in RBC, Hb, HCT, PLT, INR, bleeding time and increase in creatinine