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. 2004 Dec;24(24):10882–10893. doi: 10.1128/MCB.24.24.10882-10893.2004

FIG. 2.

FIG. 2.

Expression profiles of PR versus PR+RP acute promyelocytic leukemia samples. (A) Unsupervised hierarchical clustering with 7,125 genes/ESTs (rows) and nine PR acute promyelocytic leukemia samples without del(2) and 10 PR+PR acute promyelocytic leukemia samples with del(2) (columns). Each row represents one gene/EST, and each column represents one sample. The genotype and the presence of an interstitial deletion on chromosome 2 [del(2)] are indicated at the bottom of each heat map by the presence of a + symbol below the corresponding sample column. The expression level of each gene was normalized across all samples and is represented by a color, with red representing expression above the mean and green representing expression below the mean, while the color intensity corresponds to the magnitude of deviation (σ) from the mean. The color-coded scale for normalized expression values for all heat maps is located at the bottom of the figure. (B) Heat map generated with 65 genes/ESTs (rows) and 19 samples (columns). Ten genes located on the del(2) interval, defined by spectral karyotyping (megabases 85 to 140 onchromosome 2), are highlighted by a green bar to the left and right of the corresponding row in the heat map. Each row represents one gene/EST, and each column represents one sample.