FIG. 3.

Average expression levels for genes by chromosome in PR+RP and PR+XRT acute promyelocytic leukemia samples relative to PR acute promyelocytic leukemia samples. (A) We mapped 5,491 genes/ESTs to an exact genomic location. The average gene expression level was calculated for 10 PR+RP acute promyelocytic leukemia samples with del(2) and nine PR acute promyelocytic leukemia samples without del(2). A PR+RP/PR acute promyelocytic leukemia sample ratio was generated for each gene/EST. The log₂ value of each ratio was calculated, and the log₂ ratio for 50 consecutive genes on the same chromosome was averaged to generate one data point. The last data point at the right of the plot represents the average log₂ expression ratio for all probe sets unable to be assigned a genomic location (unknown, n = 1,634). (B) We mapped 5,407 genes/ESTs to a genomic location. Each data point represents the average log₂ ratio of 50 consecutive genes on a chromosome for 8 PR+XRT acute promyelocytic leukemia samples with del(2) versus nine PR acute promyelocytic leukemia samples without del(2). The last data point at the right of the plot represents the average log₂ expression ratio for all probe sets unable to be assigned a genomic location (unknown, n = 1,586). Vertical lines separate chromosomal boundaries. Circles highlight the data points located on the del(2) interval that are expressed at significantly lower levels in PR+RP and PR+XRT acute promyelocytic leukemia samples compared to PR acute promyelocytic leukemia samples.