Table 2. EFS association with conserved IKAROS-repressed and IKAROS-activated gene expression in patient cohorts separated by IKZF1 deletion/mutation status.
| Gene | US cohort | DCOG/COALL cohort | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total cohort (n = 289) | IKZF1 wild-type (n = 144) | IKZF1 mutated/deleted (n = 103) | Total cohort (n = 573) | no IKZF1 deletion (n = 371) | IKZF1 deletion (n = 139) | |||||||||||||
| Hazard ratio | 95% CI | P-value | Hazard ratio | 95% CI | P-value | Hazard ratio | 95% CI | P-value | Hazard ratio | 95% CI | P-value | Hazard ratio | 95% CI | P-value | Hazard ratio | 95% CI | P-value | |
| Ikaros-activated | ||||||||||||||||||
| CTNND1 | 1.98 | 1.26–3.15 | 1.2 × 10−3 | 1.67 | 0.80–3.44 | 1.7 × 10−1 | 1.34 | 0.75–2.42 | 3.2 × 10−1 | 2.92 | 1.93–3.96 | 2.9 × 10−8 | 2.85 | 1.60–4.52 | 2.0 × 10−4 | 2.13 | 1.19–3.77 | 1.1 × 10−2 |
| EMP1 | 2.48 | 1.54–3.85 | 5.0 × 10−5 | 2.42 | 1.19–5.23 | 1.7 × 10−2 | 1.96 | 1.11–3.61 | 2.2 × 10−2 | 2.06 | 1.41–2.89 | 1.2 × 10−4 | 2.50 | 1.42–4.01 | 1.0 × 10−3 | 1.21 | 0.68–2.14 | 5.1 × 10−1 |
| FXYD6 | 2.63 | 1.86–5.10 | 1.0 × 10−6 | 1.50 | 0.63–3.79 | 3.4 × 10−1 | 2.26 | 1.28–4.16 | 6.1 × 10−3 | 1.47 | 1.03–2.10 | 3.5 × 10−2 | 1.33 | 0.79–2.24 | 2.8 × 10−1 | 1.50 | 0.84–2.65 | 1.7 × 10−1 |
| IFITM3 | 2.54 | 1.60–4.01 | 2.0 × 10−5 | 1.39 | 0.68–2.90 | 3.7 × 10−1 | 2.06 | 1.15–3.72 | 1.6 × 10−2 | 1.79 | 1.24–2.54 | 1.7 × 10−3 | 1.39 | 0.83–2.33 | 2.2 × 10−1 | 1.89 | 1.06–3.34 | 3.1 × 10−2 |
| CTNNBIP1 | 1.32 | 0.84–2.08 | 2.9 × 10−1 | 1.32 | 0.64–2.75 | 4.5 × 101 | 1.09 | 0.61–1.95 | 7.8 × 10−1 | 1.41 | 0.98–2.01 | 6.2 × 10−2 | 1.05 | 0.62–1.76 | 8.6 × 10−1 | 1.11 | 0.62–1.96 | 7.3 × 10−1 |
| S100A16 | 1.70 | 1.08–2.70 | 3.4 × 10−2 | 1.02 | 0.49–2.10 | 9.7 × 10−1 | 0.87 | 0.48–1.56 | 6.3 × 10−1 | 1.26 | 0.88–1.81 | 2.0 × 10−1 | 2.06 | 1.20–3.39 | 8.0 × 10−3 | 0.92 | 0.52–1.64 | 7.8 × 10−1 |
| ROBO4 | 1.37 | 0.87–2.16 | 1.5 × 10−1 | 1.17 | 0.57–2.43 | 6.7 × 10−1 | 1.17 | 0.65–2.10 | 5.9 × 10−1 | 1.69 | 1.17–2.40 | 4.7 × 10−3 | 1.16 | 0.69–1.96 | 5.7 × 10−1 | 2.07 | 1.16–3.64 | 1.4 × 10−2 |
| AGAP3 | 1.93 | 1.24–3.11 | 1.7 × 10−3 | 1.91 | 0.92–3.95 | 8.5 × 10−2 | 1.48 | 0.84–2.72 | 1.8 × 10−1 | 1.64 | 1.14–2.33 | 7.4 × 10−3 | 1.36 | 0.81–2.28 | 2.5 × 10−1 | 1.54 | 0.87–2.74 | 1.4 × 10−1 |
| ITPRIPL2 | 1.56 | 0.99–2.47 | 4.6 × 10−2 | 1.87 | 0.90–3.88 | 9.4 × 10−2 | 0.90 | 0.50–1.62 | 7.3 × 10−1 | 2.17 | 1.49–3.05 | 3.5 × 10−5 | 1.93 | 1.13–3.19 | 1.6 × 10−2 | 2.01 | 1.13–3.58 | 1.8 × 10−2 |
| Ikaros-repressed | ||||||||||||||||||
| CSF2RB | 1.27 | 0.81–2.01 | 3.0 × 10−1 | 1.27 | 0.61–2.63 | 5.2 × 10−1 | 0.60 | 0.34–1.08 | 9.1 × 10−2 | 2.20 | 1.50–3.08 | 2.8 × 10−5 | 1.59 | 0.94–2.65 | 8.6 × 10−2 | 1.54 | 0.87–2.74 | 1.4 × 10−1 |
| C1GALT1 | 0.98 | 0.62–1.54 | 9.0× 10−1 | 0.81 | 0.39–1.68 | 5.7 × 10−1 | 0.90 | 0.50–1.61 | 7.2 × 10−1 | 1.66 | 1.15–2.35 | 6.7 × 10−3 | 1.56 | 0.92–2.61 | 9.8 × 10−2 | 1.47 | 0.83–2.60 | 1.9 × 10−1 |
| ASL | 0.90 | 0.57–1.42 | 6.4 × 10−1 | 1.03 | 0.50-2.13 | 9.4 × 10−1 | 1.11 | 0.57–1.82 | 9.6 × 10−1 | 1.28 | 0.89–1.82 | 1.8 × 10−1 | 1.67 | 0.99–2.80 | 5.6 × 10−1 | 0.85 | 0.48–1.50 | 5.7 × 10−1 |
| ORAI2 | 1.69 | 1.08–2.68 | 2.4 × 10−2 | 2.11 | 1.01-4.33 | 4.8 × | 0.89 | 0.50–1.59 | 6.9 × 10−1 | 1.47 | 1.03–2.10 | 3.5 × 10−2 | 1.08 | 0.64–1.81 | 7.8 × 10−1 | 1.56 | 0.88–2.76 | 1.3 × 10−1 |
Log rank P-values are shown. Genes where EFS is not significantly different (P > 0.05) are italicized.