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. 2017 Mar 6;214(3):669–680. doi: 10.1084/jem.20161435

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Figure 6. — Increased Th2 cytokine production in STAT3^mut and ERBB2IP^mut individual CD4 lymphocytes ex vivo. (A) Ex vivo cytokine expression in control (n = 10), ERBB2IP^mut (n = 3), and STAT3^mut memory (n = 9; CD45RO⁺) CD4 T cells. (B) Th2 cytokine expression of STAT3-mutant patients (STAT3^mut) with SH2-domain mutations (n = 3) or DNA-binding–domain mutations (n = 4). (C) Ex vivo IL-17 expression in control (n = 6) and ERBB2IP^mut (n = 3) and IL-21 expression in control (n = 4), ERBB2IP^mut (n = 2), and STAT3^mut memory (n = 2; CD45RO⁺) CD4 T cells. Data are combined from at least two independent experiments and are represented as the mean ± SEM. Mann-Whitney tests were used. *, P < 0.05; **, P < 0.005.