. 2017 Mar 6;214(3):669–680. doi: 10.1084/jem.20161435

Table 1. Immunological findings among ERBB2IP^mut individuals.

	Cell counts			Serum Ig				Antibody titers		Lymphocyte subsets						Serum tryptase
										CD4⁺		CD8⁺		CD20⁺
	ALC	ANC	AEC	IgG	IgA	IgM	IgE	Tetanus	Pneumococcus	Total	Memory^a	Total	Memory^a	Total	Memory^b
	cells/µL	cells/µL	cells/µL	mg/dL	mg/dL	mg/dL	IU/ml	IU/ml	>1.3 µg/ml	cells/µl	%	cells/µl	%	cells/µl	%	ng/ml
Ref.	1,320– 3,570	1,780– 5,380	40–540	700– 1,600	91–499	34–342	0–90	>0.15	16/23	359– 1,565	13–50	178–853	3–16	59–329	0.8–3.6	<11.4
14-y M	3,290– 4,550^c	1,430– 2,410	520– 2,880	368– 898	16–51	45–115	333–898	2.21	21/23	1,670	7.2	952	2	438	1.5	5.3
11-y F	4,450– 7,720^c	1,410– 1,860	90–680	693–737	68–89	90–102	10–98	0.35	20/23	2,506	9	1,501	5.1	794	3.4	4.2
43-y M	2,060–3,010	1,810–4,290	80–310	946–1,290	137–194	55–82	20–200	1.62	13/23	1,457	20	461	5.5	381	1.7	5.2

Abbreviations used: AEC, absolute eosinophil count; ALC, absolute lymphocyte count; ANC, absolute neutrophil count; F, female; M, male; Ref., reference range; y, year old.

T cell memory was defined as CD45RO⁺.

B cell memory was defined as CD27⁺.

Increased total lymphocyte counts and reduced memory populations relative to adult reference values are a result of the young age of these individuals and do not represent defective memory formation or other pathology.

Table 1. Immunological findings among ERBB2IPmut individuals.

Table 1. Immunological findings among ERBB2IP^mut individuals.