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. 2017 Mar 7;7:43920. doi: 10.1038/srep43920

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Copyright © 2017, The Author(s)

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(a) The protocols to investigate the antibody production induced by the Ang II vaccine and the effect of the treatment with the Ang II vaccine. (b) The serum anti-Ang II antibody titer. Sham + vehicle, n = 9; Sham + KLH, n = 5; Sham + Ang II vaccine, n = 5; MI + KLH, n = 11; MI + Ang II vaccine, n = 14. *p < 0.05 vs. Sham + KLH; #p < 0.05 vs. MI + KLH. Tukey–Kramer post hoc test. ND, not detected. (c) The serum anti-Ang II antibody titer in the MI + Ang II vaccine (post-MI) group. MI + KLH, n = 11; MI + Ang II vaccine (post-MI), n = 10. *p < 0.05 by the Student’s t-test. ND, not detected. (d) Comparison of the reactivity of commercial anti-Ang II monoclonal antibody and immunized serum derived from Ang II vaccine-injected rats.