TABLE 1.

Plasma lipid profiles in WT and APOC3-tg mice on high fructose diet

APOC3-tg and WT littermates (male, 8 weeks old) were fed a high fructose diet for 16 weeks, followed by the determination of plasma TG, cholesterol, and NEFA levels after 16 h of fasting. Mice were euthanized after 16 weeks of high fructose feeding under non-fasting conditions for the determination of hepatic TG and cholesterol content.

Genotype	WT	APOC3-tg
Body weight (g)	25.6 ± 1.2	25.2 ± 1.7
Plasma TG (mg/dl)	87 ± 6	580 ± 60a
Plasma cholesterol (mg/dl)	149 ± 13	236 ± 49b
Plasma NEFA (mmol/liter)	1.2 ± 0.07	2.6 ± 0.27b
Hepatic TG (mg/g protein)	510 ± 61	615 ± 194
Hepatic cholesterol (mg/g protein)	66 ± 7	76 ± 8

^a p < 0.001 versus WT control.

^b p < 0.05 versus WT control.