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Permeability of iso-α-acids through the blood-brain barrier. A–D, HPLC-MS/MS chromatograms of an IHE (sample for administration) (A), vehicle (B), IHE containing 0.5 g/kg of iso-α-acids (C), and IHE containing 2 g/kg of iso-α-acids (D). The peaks are labeled according to the compounds shown in Fig. 7.
