A, effect of TDYA treatment on liver NAD+/NADH level in rats fed a high fat-diet. B, hepatic expression of SIRT1 in rats treated with normal diet, high fat diet, or HFD with TDYA for 8 weeks. C, effect of TDYA on the phosphorylation level of AMPK (Thr-172) in livers of the high fat diet-fed rats. D, effect of TDYA on the phosphorylation level of ACC (Ser-79) in livers of high fat diet-fed rats. E, effect of TDYA on the phosphorylation level of p70S6K (Thr-389) in the livers of the high fat diet-fed rats. F, effect of TDYA treatment on liver mRNA expression level of PGC-1α. n = 6–8 for each group. AU, arbitrary units. #, p < 0.05, ##, p < 0.01, **, p < 0.01.