FIGURE 6.

Anti-TfR LALA-PG bispecific antibodies do not deplete reticulocytes. A, no statistically significant reticulocyte depletion was observed with mIgG2a LALA-PG at 24 h post-dose. B, antibody levels are within the expected historical range. Some increase in antibody clearance is observed with anti-TfR^m, a murinized version of anti-TfR^D. C, pharmacokinetics analysis of non-targeting murine IgG2a LALA-PG (red) antibodies is similar to historic values (gray) for other non-targeting antibodies with wild-type effector regions.