Table 3. Cytokines and chemokines significantly associated with PD-L1 expression: serum HER-2/neu (sHER2neu), C-C chemokine ligand 22 (CCL22), soluble epidermal growth factor receptor (sEGFR), Granulocyte-macrophage colony-stimulating factor (GM-CSF), C-C chemokine ligand 23 (CCL23), platelet endothelial cell adhesion molecule (PECAM-1), C-X-C motif chemokine 11 (CXCL11), macrophage migration inhibitory factor (MIF), interleukin 5 (IL5), interleukin 2 receptor (IL2R), interalukin 10 (IL10).
| ID | logFC | Abundance | FDR |
|---|---|---|---|
| Set one | |||
| sHER2neu | 0.13 | 13.11 | 8.9 |
| CCL22 | 0.17 | 9.56 | 9.6 |
| Leptin | 0.52 | 12.45 | 9.6 |
| sEGFR | 0.13 | 14.77 | 9.6 |
| GM-CSF | 0.27 | 5.83 | 9.6 |
| CCL23 | −0.19 | 8.50 | 9.6 |
| PECAM-1 | 0.07 | 11.80 | 9.6 |
| CXCL11 | −0.24 | 5.78 | 14.8 |
| MIF | 0.45 | 11.17 | 17.8 |
| Set two | |||
| IL5 | −0.28 | 1.72 | 12.7 |
| IL2R | −0.32 | 8.27 | 12.8 |
| IL10 | −0.36 | 2.84 | 12.8 |
LogFC, log2 fold change correlating with log2 PD-L1 abundance values; Abundance, mean log2 abundance in serum; FDR, false discovery rate (%).