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. 2017 Mar 7;7:43673. doi: 10.1038/srep43673

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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A single miRNA species negatively controls the expression of the ceRNA species ceRNA_T (‘target’, level m_T) and ceRNA_C (‘competitor’, level m_C), to which it can bind with rates and , respectively. The functional products of the ceRNAs, proteins p_T and p_C, can eventually interact to form a complex C_P. The key control parameter is the target’s transcription rate b_T. See Fig. 7 for a detailed scheme that includes all processes.

Inline graphic — A single miRNA species negatively controls the expression of the ceRNA species ceRNA_T (‘target’, level m_T) and ceRNA_C (‘competitor’, level m_C), to which it can bind with rates and , respectively. The functional products of the ceRNAs, proteins p_T and p_C, can eventually interact to form a complex C_P. The key control parameter is the target’s transcription rate b_T. See Fig. 7 for a detailed scheme that includes all processes.