Figure 3. ceRNA competition can stabilize highly expressed proteins.
(A) Coefficient of variation of pT as a function of the mean protein level for a post-transcriptionally unregulated protein (black line, and
), a miRNA-regulated protein (red line,
and
) and a ceRNA-regulated protein (blue line,
and
). (B) Capacity of the target’s expression channel as a function of the miRNA-competitor interaction strength. Color code same as in panel A. (C) Derepression size ΔC of the competitor as a function of the miRNA-competitor interaction strength in the case of ceRNA regulation (same parameters as panel B).