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. 2017 Mar 7;7:43523. doi: 10.1038/srep43523

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Mean diffusivity (MD) associated genes are clustered by Spearman’s rank correlation into two clusters. Bars below the heatmap describe IDH1-status and expression subgroup of each patient. (B) Weighted Gene Co-Expression Network Analysis of the whole transcriptomic data. In the bottom panel the detailed branches of module 2 and 3 are presented. Correlation heatmaps of MD and module contained genes are given in the bottom panel. (C) Scatterplots of intramodule connectivity (KME) confirmed the strong correlation of MD and module 2 and 3. (D) Gene Set Enrichment Analysis of module 2 identified voltage-gated channel activation (bottom left panel), module 3 was associated with synaptic transmission (bottom right panel). (E) Survival analysis of patients of cluster I and cluster II (derived from A) shows a significantly different OS with a more favourable outcome for the cluster with the higher MD (mean 1.27 ± 0.33) versus the cluster with the lower MD (mean 0.97 ± 0.05), p = 0.039. (F) Network analysis of module 3 (derived from (B)). Size and colours indicate the intensity of intramodule connectivity.