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. 2017 Mar 1;8:14585. doi: 10.1038/ncomms14585

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Copyright © 2017, The Author(s)

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(a) No oestrogenic activities of BHPF were observed by yeast two-hybrid assay. (b) The anti-oestrogenic activity of BHPF in comparison with that of OHT was shown by yeast two-hybrid assay. (c) No oestrogenic activities of BHPF were observed by dual-luciferase reporter assay for oestrogen receptor α. (d) The anti-oestrogenic activity of BHPF in comparison with that of OHT was shown by dual-luciferase reporter assay for oestrogen receptor α. (e) No oestrogenic activities of BHPF were observed by dual-luciferase reporter assay for oestrogen receptor β. (f) The anti-oestrogenic activity of BHPF in comparison with that of OHT was shown by dual-luciferase reporter assay for oestrogen receptor β. (g) Interaction between BHPF and the active site in human oestrogen receptor α structure (3ERT) for antagonist; dotted lines indicate hydrogen bonds between the chemical and amino acid residues. (h) Simulated binding pose of BHPF in the antagonist pocket of human oestrogen receptor α structure (3ERT) viewed from different angles. The yeast two-hybrid assays were performed in triplicate; the dual-luciferase reporter assays were performed in quadruplicate. Error bars indicate the s.d.'s from the average.