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. 2004 Dec;24(24):10933–10940. doi: 10.1128/MCB.24.24.10933-10940.2004

FIG. 4.

FIG. 4.

Secretory activity and responsiveness to hypoxia of CB cells. (A and B) Secretory response to hypoxia of CB cells of SDHD+/+ (A) and SDHD+/− (B) mice. Spike-like quantal events correspond to catecholamine release from individual vesicles. Cumulative secretion (in femtocoulombs) for each experiment is shown. (C) Quantification of the secretory response to low O2 tension (in femtocoulombs/last minute of hypoxia) in SDHD-deficient (5,105 ± 810 fC/min [mean ± standard error]; n = 16) and wild-type (3,539 ± 603 fC/min; n = 18) mice (P = 0.12 by analysis of variance). (D) Quantification of the spontaneous secretory activity in CB slices from SDHD+/+ (462 ± 94 fC/min [mean ± standard error]; n = 16) and wild-type (198 ± 35 fC/min; n = 18) mice (P = 0.01 by the Kruskal-Wallis test). (E) Spontaneous secretory activity in a SDHD+/− CB cells and reversible blockade by application of 0.3 mM extracellular cadmium.