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The landscape of the identified mutations in seven anti-human epidermal growth factor receptor 2-targeted therapy-resistant genes. The number shown in the box meant the mean allele frequency of the identified mutations in that gene. R: Resistant group. EGFR: Epidermal growth factor receptor; GNAS: Guanine nucleotide-binding protein alpha stimulating; HRAS: HRas proto-oncogene; MLH1: mutL homolog 1; CDH1: Cadherin 1; NRAS: Neuroblastoma RAS viral oncogene homolog.
