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. 2017 Mar 6;17:172. doi: 10.1186/s12885-017-3163-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Immune responsiveness of woodchucks with increasing viral loads following a single IV dose of JVRS-100. Fold increase in mRNA expression of cytokines and T cell surface markers in peripheral blood following a single IV dose of JVRS-100 at a concentration of 50 or 100 μg/animal into woodchucks with low (n = 2) versus high (n = 2) serum WHV DNA loads. Results are presented as a change from the transcription level observed in control woodchucks with comparable low (n = 2) or high (n = 2) viral loads following a single IV dose of placebo. Vertical lines denote standard deviations