Fig. 6.

Intrahepatic expression of cytokines and T cell surface markers mediated by JVRS-100 in chronic WHV infected woodchucks with HCC. Fold increase in mRNA expression of cytokines and T cell surface markers in liver of woodchucks with pre-existing liver cancer during and following IV treatment with JVRS-100 at concentrations of 100 μg/animal (low dose; n = 3) (a) or 300 μg/animal (high dose; n = 3) (b). Results are presented as a change from the transcription level observed in control woodchucks during and following IV treatment with vehicle (placebo; n = 6). Vertical lines denote standard deviations