Table 4.
Gene | SNP | Chr | Position | Effect allele | GS minor allele frequency | HRC MAF | GS p value | GS effect size | Meta top SNP | Meta p value |
---|---|---|---|---|---|---|---|---|---|---|
SLC2A9 | rs6449213 | 4 | 9994215 | T | 0.165 | 0.1857 | 1.93E-17 | 0.592 | rs12498742 | <1 Eāāā700 |
FAM134B | rs75869162 | 5 | 16617922 | A | 0.005 | 0.0019 | 1.57E-08 | 2.24 | rs386845 | 1.18E-02 |
RP11-430H10.4 | rs141208451 | 11 | 45538920 | A | 0.005 | 0.0011 | 3.13E-09 | 2.32 | rs11038475 | 7.36E-03 |
ZNF160 | rs187171029 | 19 | 53599256 | T | 0.006 | 0.0040 | 1.84E-08 | 2 | rs16984293 | 2.58E-02 |
Summary of top hits of the imputed GWAS analysis of uric acid in 2077 Generation Scotland participants, compared with top hits in a meta-analysis reported in the GUGC. Top hits were extracted from the region within 100,000 bases of the imputed GWAS top SNP. Entries in bold are within 500,000 bases of a SNP that reached genome-wide significance in the genotyped GWAS analysis