FIG. 2.

Correlation between spleen weight and hemoglobin content or platelet counts in GATA-1.05/X mice. After we screened both hemoglobin and platelet counts from 265 live GATA-1.05/X mice, the spleens were removed and their weights were measured. Red spots indicate 131 mice that were 49 to 149 days old, green spots indicate 107 mice that were 150 to 299 days old, and blue spots indicate 27 mice that were more than 300 days old. Simple regression equations demonstrate linkages between spleen weight (Sp) and hemoglobin content (Hb) as follows: Hb = −3.1Sp + 14.2 (P < 0.0001) (A) and spleen weight and platelet counts (Plt) (Plt = −16.7Sp + 63.2 (P < 0.0001) (B). The regression lines are superimposed in the figures. Note that spleen weight was not related to the age of the mice. Dashed line, grossly enlarged spleens.