Table 2.

Univariate Cox proportional regression models with death for all-causes as outcome

		UnadjustedCox proportional models		Unadjustedtime-dependent Cox proportional models
Variables	Categories	HR (95% CI)	P value	HR (95% CI)	P value
PLR	<100	1.38 (1.10–1.73)	0.006	1.21 (0.95–1.53)	NS
	100–200	Ref		Ref
	≥200	2.27 (1.77–2.92)	<0.001	3.87 (2.97–5.05)	<0.001
NLR	<2	Ref		Ref
	2–4	1.54 (1.19–1.99)	0.001	2.21 (1.71–2.89)	<0.001
	≥4	3.27 (2.36–4.53)	<0.001	8.06 (5.90–11.0)	<0.001

Time-dependent Cox regression models, CD8 CD4 ratio, PLR, NLR were considered at enrolment and every year. The observational period were divided into intervals of 1 year duration

Abbreviations: HR hazard ratio, 95% CI 95% confidence interval, PLR platelet to lymphocyte ratio, NLR neutrophil to lymphocyte ratio