Table 1.

Zoledronic acid-induced modifications to bone marrow hematopoietic and progenitor cell numbers over time

Average numbers of indicated bone marrow HPC populations (number of cells ± SEM) from nude and C57BL/6 mice as determined by flow cytometry on one femur per mouse at indicated time points following control (CTL) or one 100 μg/kg dose of zoledronic acid (ZOL) treatment; n = 15; N = 5 mice per group × three biological replications. Dark yellow shaded boxes represent statistical significance relative to CTL; p values indicated. d. day, LT-HSCs long-term HSCs, ST-HSCs short-term HSCs, LSKs Lin-Sca1+cKit+, MPPs multipotent progenitor populations, CMPs common myeloid progenitors, MEPs megakaryocyte/erythroid progenitors, GMPs granulocyte/monocyte progenitors, LBPs lymphoid-biased progenitors, CLPs common lymphoid progenitors