Table 5.
MHC class II specific top scored antigenic peptides along with associated alleles
| Start | Peptide | MHC-II binding scorea | Allele (Human Leukocyte Antigen [HLA] specific) |
Antigenic Scoreb |
|---|---|---|---|---|
| 55 | EVRSYYYHASVTDIS | 0.25–1.76 | DRB1*03:05,DRB1*04:01,DRB1*04:08,DRB1*04:09,DRB1*04:07,DRB1*04:21, DRB1*04:17,DRB1*04:26,DRB1*04:62,DRB1*04:69,DRB1*04:74,DRB1*04:82, DRB1*07:03,DRB1*07:01,DRB1*08:04,DRB1*09:07,DRB1*09:04,DRB1*09:01, DRB1*09:09,DRB1*11:02,DRB1*11:21,DRB1*13:22,DRB1*15:06,DRB1*15:02 |
0.9127 |
| 95 | GFTDRGWGKGCGLFG | 5.37–17.95 | DRB1*01:02,DRB1*03:05,DRB1*07:03,DRB1*08:01,DRB1*11:01,DRB1*11:28, DRB1*13:05,DRB1*13:21,DRB1*15:02,DRB1*15:06,DRB5*01:05 |
0.9232 |
| 380 | DSYIVVGRKDKQINH | 0.1–1.97 | DRB1*03:06,DRB1*03:05,DRB1*03:01,DRB1*03:08,DRB1*03:07,DRB1*08:01, DRB1*08:04,DRB1*08:06,DRB1*11:01,DRB1*11:07,DRB1*13:07,DRB1*13:04, DRB5*01:01,DRB5*01:05 |
1.5861 |
| 383 | IVVGRKDKQINHHRH | 0.4–4.04 | DRB1*03:06,DRB1*03:05,DRB1*03:01,DRB1*03:08,DRB1*03:07,DRB1*04:02, DRB1*08:01,DRB1*08:04,DRB1*08:06,DRB1*08:13,DRB1*11:02,DRB1*11:07, DRB1*11:21,DRB1*13:01,DRB1*13:04,DRB1*13:27,DRB1*13:22 |
1.1724 |
aPercentile score vary in allele specific manner. The less the score better is the binding. The range of scores was obtained by setting cut off. bAntigenic score was computed using Doytchinova and Flower's (2007) method [47]
Epitopes were further checked for their efficacy in interactions at the peptide binding groove (see below)