Table 2.
Correlation analysis of the variation of the 3PGA pool compared to all monitored metabolites of this study
| Metabolite | Pearson’s correlation coefficient (r) of normalized responses | ||
|---|---|---|---|
| All samples | Wild type | Producer | |
| Positive correlation | |||
| Glyceric acid-3-phosphate | 1.000 | 1.000 | 1.000 |
| Glyceric acid-2-phosphate | 0.806 | 0.767 | 0.450 |
| Glutamic acid | 0.821 | 0.755 | 0.557 |
| Glutamine (pyroglutamic acid, glutamate)a | 0.810 | 0.727 | 0.689 |
| Glutamic acid, N-acetyl- | 0.821 | 0.712 | 0.676 |
| A112003 | 0.716 | 0.789 | 0.718 |
| Negative correlation | |||
| Mannose | 0.408 | −0.956 | −0.615 |
| Glucose | 0.112 | −0.774 | −0.557 |
| Fructose | 0.068 | −0.760 | −0.640 |
| Phenylalanine | 0.011 | −0.700 | −0.642 |
| A214003 | 0.224 | −0.733 | −0.718 |
| A311002 | −0.159 | −0.732 | −0.498 |
Pearson’s correlation coefficient of the WT subset were ranked and filtered by r > 0.70 or r < −0.70
Correlation coefficients of normalized responses from all, WT, or producer samples are reported. The complete data set can be found in Additional file 1
aPyroglutamic acid represents the sum of the glutamine, pyroglutamic and glutamic acid pool