Table 1. Descriptive characteristics of 15,596 ovarian cancer cases and 23,236 controls from the Ovarian Cancer Association Consortium (OCAC).
| Variable | Case N = 15596 | Control N = 23236 | P value |
|---|---|---|---|
| Age1 | 57.36 (11.70) | 55.61 (11.90) | <0.0001 |
| Ethnicity2 | |||
| Non-Hispanic | 13847 (99.6) | 21539 (99.7) | 0.03 |
| Hispanic | 56 (.4) | 59 (.3) | |
| Missing | 1693 | 1638 | |
| Family history of ovarian cancer2 | |||
| No | 5891 (91.6) | 7643 (95.7) | <0.0001 |
| Yes | 543 (8.4) | 343 (4.3) | |
| Missing | 9162 | 15250 | |
| Height1 | 1.64 (0.07) | 1.63 (0.06) | <0.0001 |
| Missing | 4571 | 6596 | |
| Weight1 | 57.2 (9.80) | 56.4 (8.71) | |
| Missing | 6600 | 9277 | <0.0001 |
| Body Mass Index (BMI)1 | 21.29 (3.43) | 21.18 (3.06) | 0.01 |
| Missing | 6642 | 9311 | |
| Age at menarche1 | 12.8 (1.60) | 12.9 (1.68) | 0.02 |
| Missing | 4914 | 7195 | |
| Total number of pregnancies1 | 2.37(1.80) | 2.63(1.74) | <0.0001 |
| Missing | 4879 | 7066 | |
| Breast feeding2 | |||
| No | 3070 (40.5) | 4078 (30.2) | <0.0001 |
| Yes | 4502 (59.5) | 9426 (69.8) | |
| Missing | 8024 | 9732 | |
| Menopausal status2 | |||
| Pre/perimenopausal | 3585 (32.4) | 4519 (28) | <0.0001 |
| Post-menopausal | 7491 (67.6) | 11640 (72.0) | |
| Missing | 4520 | 7077 | |
| HRT2 | |||
| No | 2675 (44.3) | 3237 (44.6) | 0.73 |
| Yes | 3366 (55.7) | 4025 (55.4) | |
| Missing | 9555 | 15974 | |
| OC use2 | |||
| Never | 4465 (41.9) | 6054 (37.4) | <0.0001 |
| Ever | 6191 (58.1) | 10152 (62.6) | |
| Missing | 4940 | 7030 | |
| OC use in months1 | 38.21 (59.83) | 49.40(69.27) | <0.0001 |
| Missing | 5164 | 7209 | |
| Tubal ligation2 | |||
| No | 8420 (84.4) | 8278 (76.7) | <0.0001 |
| Yes | 1562 (15.7) | 2514 (23.3) | |
| Missing | 5614 | 12444 | |
| Endometriosis2 | |||
| No | 7435 (90.8) | 10030 (93.2) | <0.0001 |
| Yes | 755 (9.2) | 731 (6.8) | |
| Missing | 7406 | 12475 | |
| Hysterectomy2 | |||
| No | 7352 (68.3) | 13103 (81.2) | <0.0001 |
| Yes | 3413 (31.7) | 3025 (18.8) | |
| Missing | 4831 | 7108 | |
| Clinical characteristics Histology2 | |||
| Serous | 9330 (59.8) | ||
| Mucinous | 1592 (10.2) | ||
| Endometrioid | 2099 (13.5) | ||
| Clear cell | 1033 (6.6) | ||
| Mixed Cell | 505 (3.2) | ||
| Other | 1037 (6.7) | ||
| Behavior2 | |||
| LMP | 1724 (11.1) | ||
| Invasive | 13872 (88.9) | ||
| FIGO stage2 | |||
| 1 | 3488 (31.7) | ||
| 2 | 1147 (10.4) | ||
| 3 | 5412 (49.2) | ||
| 4 | 954 (8.7) | ||
| Grade2 | |||
| Well differentiated | 1240 (12.5) | ||
| Moderately differentiated | 2427 (24.4) | ||
| Poorly differentiated | 5591 (56.2) | ||
| Undifferentiated | 699 (7.0) | ||
| Missing | 5639 | ||
1
Mean (standard deviation),
2
N(%), CI = Confidence interval, BMI = body mass index, HRT = hormone replacement therapy, OC = oral contraceptive, LMP = low malignant potential