Table 2. Admixture maximum likelihood gene burden p-values for each gene in the Treg cell pathway and overall considering all genes.
Gene | Serous (n = 9,330) | High-grade serous (n = 5,792) | Endometrioid (n = 2,060) | Clear cell (n = 1,021) | Invasive Mucinous (n = 933) |
---|---|---|---|---|---|
CTLA4 | 0.612 | 0.984 | 0.337 | 0.471 | 0.178 |
FCRL3 | 0.426 | 0.388 | 0.464 | 0.546 | 0.110 |
FOXP3 | 0.362 | 0.254 | 0.630 | 0.525 | 0.287 |
GZMB | 0.484 | 0.203 | 0.220 | 0.931 | 0.847 |
HDAC9 | 0.679 | 0.864 | 0.212 | 0.398 | 0.990 |
IL12B | 0.005 | 0.008 | 0.127 | 0.915 | 0.088 |
IL17RA | 0.269 | 0.243 | 0.974 | 0.831 | 0.652 |
IL23A | 0.137 | 0.111 | 0.990 | 0.431 | 0.561 |
IL23R | 0.423 | 0.903 | 0.470 | 0.101 | 0.221 |
IL2RA | 0.948 | 0.960 | 0.153 | 0.281 | 0.148 |
IL7 | 0.915 | 0.933 | 0.339 | 0.822 | 0.670 |
IL7R | 0.558 | 0.562 | 0.296 | 0.459 | 0.670 |
IL8RA | 0.118 | 0.084 | 0.035 | 0.344 | 0.035 |
LGALS1 | 0.222 | 0.054 | 0.841 | 0.520 | 0.030 |
LGALS9 | 0.958 | 0.949 | 0.649 | 0.885 | 0.081 |
PRKCQ | 0.511 | 0.862 | 0.879 | 0.528 | 0.729 |
STAT5A | 0.283 | 0.463 | 0.556 | 0.117 | 0.442 |
STAT5B | 0.721 | 0.873 | 0.412 | 0.022 | 0.297 |
TGFB1 | 0.864 | 0.908 | 0.864 | 0.966 | 0.168 |
TGFB2 | 0.739 | 0.418 | 0.481 | 0.087 | 0.672 |
TGFB3 | 0.335 | 0.250 | 0.139 | 0.354 | 0.438 |
TGFBR1 | 0.378 | 0.398 | 0.021 | 0.504 | 0.493 |
TGFBR2 | 0.644 | 0.242 | 0.017 | 0.001 | 0.025 |
TGFBR3 | 0.068 | 0.256 | 0.446 | 0.295 | 0.366 |
TNFSF14 | 0.742 | 0.521 | 0.964 | 0.981 | 0.848 |
Treg cell gene pathway | 0.444 | 0.719 | 0.082 | 0.083 | 0.632 |