Figure 7.

Model summary. (A) Schematics of the functional roles of SF-mediated negative feedback. (i) Without the negative feedback, the actomyosin contractility eventually matches the mechanical strength of the FA-ECM linkage and becomes saturated when the ECM is stiffer than the FA. (ii) SF-mediated negative feedback downregulates actomyosin contractility. (iii) Schematic comparisons of FA mechanosensing of ECM stiffness under four conditions: with a static or dynamic FA, and with or without SF-mediated negative feedback. (B) Model summary of the sequential actions of the two distinct actin networks in promoting FA growth. To see this figure in color, go online.