Table 1. Association of FILIP1L, Beta-catenin, and SLUG expression with clinicopathological characteristics in normal and neoplastic ovarian tissue samples.
No | FILIP1L | Beta–catenin | SLUG | ||||
---|---|---|---|---|---|---|---|
Median [IQR] | p value | Median [IQR | p value | Median [IQR] | p value | ||
Diagnostic category | |||||||
Normal | 64 | 88 [50–142] | < 0.001 | 54 [30–89] | < 0.001 | 110 [79–173] | < 0.001 |
Benign | 29 | 84 [39–140] | 66 [34–100] | 141 [86–195] | |||
Borderline | 50 | 59 [29–105] | 84 [60–128] | 131 [68–183] | |||
Cancer | 182 | 50 [13–109] | 106 [71–150] | 144 [91–183] | |||
Metastatic | 46 | 35 [12–60] | 100 [70–131] | 224 [162–266] | |||
Age | |||||||
≤ 50 | 85 | 56 [18–123] | 0.032 | 110 [59–149] | 0.808 | 146 [99–180] | 0.755 |
> 50 | 97 | 41 [7–85] | 99 [74–150] | 143 [83–196] | |||
Histological subtype | |||||||
Serous | 123 | 50 [17–101] | 0.914 | 101 [73–145] | 0.531 | 146 [86–197] | 0.647 |
Others | 59 | 55 [7–119] | 110 [64–170] | 140 [107–165] | |||
FIGO stage | |||||||
I/II | 48 | 91 [30–122] | 0.007 | 101 [60–143] | 0.535 | 136 [81–163] | 0.102 |
III/IV | 121 | 41 [11–76] | 101 [74–150] | 145 [91–199] | |||
Tumor grade | |||||||
Well + Moderate | 78 | 51 [12–110] | 0.916 | 110 [80–161] | 0.144 | 143 [83–179] | 0.589 |
Poor | 91 | 50 [16–104] | 98 [60–143] | 140 [91–181] | |||
CA125 | |||||||
≤ 35 | 24 | 43 [20–130] | 0.238 | 99 [60–134] | 0.632 | 136 [87–155] | 0.290 |
> 35 | 154 | 51 [11–102] | 106 [73–151] | 145 [91–183] | |||
Chemosensitivity | |||||||
Sensitive | 152 | 55 [16–113] | 0.002 | 104 [70–150] | 0.182 | 141 [90–182] | 0.041 |
Resistant | 12 | 5.5 [0–27] | 136 [89–155] | 168 [147–190] |
Calculated only 169 cases with available information of FIGO stage and tumor grade.
Calculated only 178 cases with available information of CA125.
Calculated only 163 cases with available information of chemosensitivity.
Protein expression was determined through analysis of an immunohistochemically stained tissue array, as described in the materials and methods section.