Table 3. IPA top disease and function networks.
| SIN3A knockdown | ||
|---|---|---|
| Consistency Score | Diseases and functions | Target molecules in dataset* |
| 61 | angiogenesis, branching of cells, cell death of cancer cells, cell survival, development of body trunk, growth of neurites, growth of tumor, outgrowth of cells, S phase, sarcoma, vascular disease | ABCC3, ANPEP, ATF3, BTG2, CASP1, CCND2, CDH11, COL1A1, CXCL12, CYP11A1, CYP1A1, DCN, E2F2, FOS, GNAO1, GREM1, HBA1/HBA2, IL18, KITLG, MMP1, MMP2, NES, NR4A1, PDE4B, POSTN, PPFIA4, PTPRE, RGS4, RRAD, S1PR1, SLC16A1, SLCO1B3, TINAGL1 |
| 35 | angiogenesis, cell death of cancer cells, colony formation of cells, development of body trunk, growth of neurites, growth of tumor, S phase, sarcoma, synthesis of hormone, vascular disease | ANPEP, ATF3, BTG2, CASP1, CCND2, CDH11, COL1A1, CXCL12, CYP11A1, CYP1A1, DCN, DIO2, E2F2, FOS, GNAO1, GREM1, HBA1/HBA2, IL18, KITLG, MMP1, MMP2, NES, NR4A1, PDE4B, PTPRE, RGS4, RRAD, S1PR1, SLC16A1, THY1, TINAGL1 |
| 33 | angiogenesis, branching of cells, cell death of cancer cells, cell survival, colony formation of cells, connective or soft tissue tumor, development of body trunk, growth of neurites, growth of tumor, S phase, vascular disease | ABCC3, ANPEP, ATF3, BTG2, CCND2, CDH11, COL1A1, CXCL12, CYP11A1, CYP1A1, E2F2, FOS, GNAO1, GREM1, HBA1/HBA2, IL18, KITLG, MMP1, MMP2, NES, NR4A1, PDE4B, POSTN, PPFIA4, PTPN7, PTPRE, RGS4, RRAD, S1PR1, SLC16A1, SLCO1B3, THY1 |
| SIN3B knockdown | ||
|---|---|---|
| Consistency Score | Diseases and functions | Target molecules in dataset* |
| 22 | cell movement of endothelial cells, cell viability, development of epithelial tissue, differentiation of epithelial tissue, interphase, mass of heart, vascularization of body region, vascularization of lesion | ANPEP, ATF3, BTG2, CCND2, CSF3, DCN, GADD45A, GREM1, HDAC5, HTRA1, ID3, KRT14, MAPT, MMP2, NES, NPR1, NR4A1, PTGS2, RASGRF1, RRAD, S100A4, SLC16A1, SLC2A4, SOCS2, TRADD, TSC22D1, WNT10B, WT1 |
| 15 | apoptosis of breast cancer cell lines, cell movement of endothelial cells, development of epithelial tissue, interphase, organismal death, quantity of phagocytes, vasculogenesis | ANPEP, ATF3, BIRC3, CCND2, CD68, CSF3, EGR2, GADD45A, HDAC5, KRT14, MMP2, MUC1, NES, NR4A1, PTGS2, RASGRF1, S100A4, SLC2A4, TXNIP, WNT10B, WT1 |
| 15 | development of epithelial tissue, vascularization of body region, vascularization of lesion | ANPEP, CSF3, ID3, MMP2, NR4A1, PTGS2, S100A4, STAT5A, TIE1, WNT10B, WT1 |
*
Red indicates up-regulation and green indicates down-regulation of target genes upon knockdown of SIN3A or SIN3B.